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TCO-PEG2-Sulfo-NHS ester (sodium)
Products Details
Product Description
– TCO-PEG2-Sulfo-NHS ester sodium is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG2-Sulfo-NHS ester (sodium) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Web ID
– HY-141172A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H29N2NaO11S
References
– [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
Molecular Weight
– 528.51
SMILES
– O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCOCCOCCNC(OC2CC/C=CCCC2)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PROTAC Linkers
Pathway
– PROTAC
Product type
– Reference compound
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