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Product Description
– TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer’s disease research[1].
Web ID
– HY-107668A
Shipping
– Room temperature
Molecular Formula
– C13H18N2
References
– [1]Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54(23):7943-61.|[2]Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524(1-3):11-8.|[3]Marrero MB, et al. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309(1):16-27.
CAS Number
– 700834-58-8
Molecular Weight
– 202.30
SMILES
– N1(CC2)C(C3=CC=CN=C3)CCC2CC1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– nAChR
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
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