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Taurolithocholic acid-d4-1 (sodium)
Products Details
Product Description
– Taurolithocholic acid-d4-1 (sodium) is the deuterium labeled Taurolithocholic acid. Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1].
Web ID
– HY-113308AS2
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H40D4NNaO5S
References
– [1]U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82.|[2]Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Molecular Weight
– 509.71
SMILES
– C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(NC([2H])([2H])C([2H])([2H])S(=O)(O[Na])=O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;Endogenous Metabolite;Isotope-Labeled Compounds
Pathway
– Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
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