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Products Details
Product Description
– Tasidotin hydrochloride is a peptide analog of the antimitotic depsipeptide dolastatin 15, as an inhibitor of microtubule assembly and microtubule dynamics.
Web ID
– HY-13760
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C32H59ClN6O5
References
– [1]Bai R, et al. Intracellular activation and deactivation of Tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Mol Pharmacol. 2009 Jan;75(1):218-26.|[2]Garg V, et al. Preclinical analysis of Tasidotin HCl in Ewing’s sarcoma, rhabdomyosarcoma, synovial sarcoma, and osteosarcoma. Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5446-54.
CAS Number
– 623174-20-9
Molecular Weight
– 643.30
SMILES
– [H]Cl.O=C(N1CCC[C@H]1C(NC(C)(C)C)=O)[C@H]2N(C([C@H](C(C)C)N(C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C)=O)=O)C)=O)CCC2
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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