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Tanshinone IIA
$37 – $220
Products Details
Product Description
– Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
Web ID
– HY-N0135
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H18O3
References
– [1]Xie J, et al. The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line. Acta Pharm Sin B. 2015 Nov;5(6):554-63.|[2]Zhang Z, et al. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. Am J Transl Res. 2016 Jul 15;8(7):3124-32.|[3]Su CC, et al. Tanshinone IIA decreases the protein expression of EGFR, and IGFR blocking the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells both in vitro and in vivo. Oncol Rep. 2016 Aug;36(2):1173-9.
CAS Number
– 568-72-9
Molecular Weight
– 294.34
Compound Purity
– 99.74
SMILES
– O=C(C1=C2C=CC3=C1CCCC3(C)C)C(C4=C2OC=C4C)=O
Clinical Information
– Phase 4
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : 1 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– VEGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
