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Product Description
– Taniborbactam (VNRX-5133) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC50s of 8-530 nM. Taniborbactam has IC50s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam is against Gram-negative bacteria[1][2].
Web ID
– HY-109124
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C19H28BN3O5
Citations
– Antimicrob Agents Chemother. 2023 May 31;e0033923.|Int J Antimicrob Agents. 2023 Nov 4:107030.|J Antimicrob Chemother. 2023 Mar 15;dkad061.|Antimicrob Agents Chemother. 2021 Nov 22;AAC0167621.
References
– [1]Krajnc A, et al. Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases. J Med Chem. 2019 Sep 26;62(18):8544-8556.|[2]Liu B ,et al. Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. J Med Chem. 2019 Dec 16.
CAS Number
– 1613267-49-4
Molecular Weight
– 389.25
SMILES
– OC(C1=C(OB(O)[C@@H](NC(C[C@@H]2CC[C@@H](NCCN)CC2)=O)C3)C3=CC=C1)=O
Clinical Information
– Phase 3
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
