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Tacrolimus-13C,d2
$1,600
Only 1000 item(s) left in stock.
Products Details
Product Description
– Tacrolimus-13C,d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].
Web ID
– HY-13756S
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C43 13CH67D2NO12
References
– [1]Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.;Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcri|[2]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886.|[3]A W Thomson, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.;Vogel KR,
CAS Number
– 1356841-89-8
Molecular Weight
– 807.02
Compound Purity
– 98.0
SMILES
– O=C(O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(C)=C/[C@H]2C[C@H]([C@@H](CC2)O)OC)[C@]3([H])CCCCN3C(C([C@]4([C@@H](C[C@@H]([C@@]([H])([C@H](C[C@H](C/C(C)=C/[C@H]1C/C=[13C]([2H])[2H])C)OC)O4)OC)C)O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Autophagy;Bacterial;FKBP;Phosphatase
Isoform
– Macrolide
Pathway
– Anti-infection;Apoptosis;Autophagy;Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
