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Products Details
Product Description
– SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%)[1].
Web ID
– HY-155681
Shipping
– Room temperature
Molecular Formula
– C47H53ClN6O5S
References
– [1]Ding Z, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66(15):10364-10380..
CAS Number
– 2922115-32-8
Molecular Weight
– 849.48
SMILES
– O=C(C1N(CCCC1)CC2=C(C=C(C(Cl)=C2)OCC3=C(C(C4=CC=CC=C4)=CC=C3)C)OCC5=CC(C#N)=CC=C5)NCCNC(CCCC[C@H]6[C@]7([H])[C@](NC(N7)=O)([H])CS6)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Monoamine Oxidase;PD-1/PD-L1
Pathway
– Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
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