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SW2_110A
$350 – $2,500
Products Details
Product Description
– SW2_110A is a selective chromobox 8 chromodomain (CBX8 ChD) inhibitor with a Kd of 800 nM. SW2_110A shows minimal 5-fold selectivity for CBX8 ChD over all other CBX paralogs in vitro[1]. SW2_110A is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-141716
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C42H60N6O7
References
– [1]Sijie Wang, et al. Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor. ACS Chem Biol. 2020 Jan 17;15(1):112-131.
Molecular Weight
– 760.96
Compound Purity
– 99.16
SMILES
– O=C(C1=CC=C(C=C1)OC2=CC=CC=C2)N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(NCC#C)=O)CO)=O)CCCCN(CC)CC)=O)[C@H](CC)C)=O)C3CCCC3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 125 mg/mL (ultrasonic)
Target
– Histone Methyltransferase
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
