Products Details

Product Description

– Sumatriptan (GR 43175) hydrochloride is an orally active 5-HT1 receptor agonist with Kis of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan hydrochloride can be used for migraine headache research[1][2].

Web ID

– HY-B0121A

Shipping

– Room temperature

Applications

– Neuroscience-Neuromodulation

Molecular Formula

– C14H22ClN3O2S

References

– [1]K L Dechant, et al. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992 May;43(5):776-98.|[2]S J Peroutka, et al. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989 Apr 12;163(1):133-6.

CAS Number

– 103628-62-2

Molecular Weight

– 331.86

SMILES

– O=S(CC1=CC2=C(NC=C2CCN(C)C)C=C1)(NC)=O.Cl

Clinical Information

– Launched

Research Area

– Neurological Disease

Solubility

– 10 mM in DMSO

Target

– 5-HT Receptor

Isoform

– 5-HT1 Receptor

Pathway

– GPCR/G Protein;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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