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Product Description
– Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].
Web ID
– HY-112847
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H37NO7S
Citations
– BMC Cancer. 2023 Apr 21;23(1):367.|Cancer Lett. 2023 Nov 25, 216511.|Cell Immunol. 11 January 2022, 104475.|CNS Neurosci Ther. 2023 May 8.|Food Res Int. 2023 Nov, 173, 113328.|Food Sci Nutr. 2023 Nov 22.|Front Pharmacol. 2020 Dec 16;11:593832.|Int J Biol Macromol. 2023 Oct 12:127324.|Int J Mol Sci. 2023 Aug 31, 24(17), 13516.|SSRN. 2023 Aug 30.|Toxicol Sci. 2022 Dec 19;kfac133.|Toxins. 2021, 13(11), 802.|J Exp Med. 2023 Mar 6;220(3):e20221316.|J Transl Med. 2023 Feb 6;21(1):89.|Research Square Preprint. 2023 Oct 11.|Research Square Print. December 29th, 2022.
References
– [1]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391(3):1348-51.|[2]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14(1):237.
CAS Number
– 135661-44-8
Molecular Weight
– 459.60
SMILES
– O=S(C(C1)C(N(OC(CCCCCCC/C=CCCCCCCCC)=O)C1=O)=O)(O)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Mitophagy
Pathway
– Autophagy
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
