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Products Details
Product Description
– Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
Web ID
– HY-B0323A
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C15H24N4O5S
References
– [1]Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34.|[2]Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387.
CAS Number
– 4299-60-9
Molecular Weight
– 372.44
SMILES
– O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O.OCCNCCO
Clinical Information
– Launched
Research Area
– Cancer; Infection; Endocrinology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Bacterial;Endothelin Receptor
Isoform
– ETA;ETB
Pathway
– Anti-infection;GPCR/G Protein
Product type
– Reference compound
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