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Stiripentol
$60 – $444
Products Details
Product Description
– Stiripentol (STP) is an anticonvulsant agent, which can inhibit N-demethylation of CLB to NCLB mediatated by CYP3A4 (noncompetitively) and CYP2C19 (competitively) with Ki of 1.59±0.07 and 0.516±0.065 μM and IC50 of 1.58 and 3.29 μM, respectively.
Web ID
– HY-103392
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H18O3
References
– [1]Giraud C, et al. In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism.Drug Metab Dispos. 2006 Apr;34(4):608-11. Epub 2006 Jan 13.|[2]Cao D, et al. Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia. 2012 Jul;53(7):1140-5.
CAS Number
– 49763-96-4
Molecular Weight
– 234.29
Compound Purity
– 99.97
SMILES
– CC(C)(C)C(O)/C=C/C1=CC=C(OCO2)C2=C1
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : 150 mg/mL (ultrasonic;warming)
Target
– Cytochrome P450
Isoform
– CYP2;CYP3
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
