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Product Description
– Staurosporine (AM-2282) (GMP) is Staurosporine (HY-15141) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases[1][2][3][4][5].
Web ID
– HY-15141G
Shipping
– Room temperature
Molecular Formula
– C28H26N4O3
References
– [1]Ganapathy PS, et al. Sensitivity of staurosporine-induced differentiated RGC-5 cells to homocysteine. Curr Eye Res. 2010 Jan;35(1):80-90.|[2]Pregi N, et al. Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells. Biochim Biophys Acta. 2006 Feb;1763(2):238-46.|[3]Hajimu MORIOKA, et al. Staurosporine-induced Differentiation in a Human Neuroblastoma Cell Line, NB-1. Agricultural and Biological Chemistry. 1985; 1959-1963.|[4]Okazaki T, et al. Staurosporine, a novel protein kinase inhibitor, enhances HL-60-cell differentiation induced by various compounds. Exp Hematol. 1988 Jan;16(1):42-8. |[5]Yuste VJ, et al. The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells. J Neurochem. 2002 Jan;80(1):126-39.
CAS Number
– 62996-74-1
Molecular Weight
– 466.53
SMILES
– O=C(NC1)C2=C1C3=C(C4=C2C5=C(C=CC=C5)N4[C@H]6C[C@@H](NC)[C@@H](OC)[C@]7(C)O6)N7C8=CC=CC=C83
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– PKC
Pathway
– Epigenetics;TGF-beta/Smad
Product type
– Reference compound
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