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Products Details
Product Description
– Spongionellol A analog 1, an analog of Spongionellol A (HY-10491), is a MDR1 (p-glycoprotein) inhibitor. Spongionellol A analog 1 has high cytotoxic activity and selectivity in prostate cancer cells by inducing caspase‑dependent apoptosis. Spongionellol A analog 1 can be used in the research of cancers, such as prostate cancer[1].
Web ID
– HY-N10492
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H38O7
References
– [1]Sergey A Dyshlovoy, et al. New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein. Sci Rep. 2022 Aug 9;12(1):13570.
Molecular Weight
– 450.57
SMILES
– CC(O[C@H]1[C@]23[C@]([C@@H](CC[C@]2([H])[C@@]4([C@@](C(C)(CCC4)C)([H])CC3)C)C(OC)=O)([H])[C@@H](O1)OC(C)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– P-glycoprotein
Pathway
– Membrane Transporter/Ion Channel
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
