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Products Details
Product Description
– Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis[1][2].
Web ID
– HY-122152
Shipping
– Room temperature
Molecular Formula
– C22H25Cl2N3OS2
References
– [1]Zhao W, et al. Spiclomazine induces apoptosis associated with the suppression of cell viability, migration and invasion in pancreatic carcinoma cells. PLoS One. 2013 Jun 20;8(6):e66362.|[2]Guo X, et al. Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer. Oncotarget. 2018 Jan 8;9(6):6938-6951.
CAS Number
– 27007-85-8
Molecular Weight
– 482.49
SMILES
– O=C1CSC2(N1)CCN(CC2)CCCN3C4=C(SC5=CC=C(C=C35)Cl)C=CC=C4.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Ras
Isoform
– K-Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
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