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Product Description
– Sp-cAMPS triethylamine, a cAMP analog, is potent activator of cAMP-dependent PKA I and PKA II. Sp-cAMPS triethylamine is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS triethylamine binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].
Web ID
– HY-110005
Shipping
– Room temperature
Molecular Formula
– C16H27N6O5PS
References
– [1]Su H Hung, et al. A new nonhydrolyzable reactive cAMP analog, (Sp)-adenosine-3′,5′-cyclic-S-(4-bromo-2,3-dioxobutyl)monophosphorothioate irreversibly inactivates human platelet cGMP-inhibited cAMP phosphodiesterase. Bioorg Chem. 2002 Feb;30(1):16-31.|[2]L Y Wang, et al. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science. 1991 Sep 6;253(5024):1132-5.|[3]Ronald Jäger, et al. Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem. 2012 Jan 6;287(2):1210-9.|[4]P A Connelly,et al. A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3′,5′-phosphorothioate. J Biol Chem. 1987 Mar 25;262(9):4324-32.|[5]G Dominguez, et al. Rescuing prefrontal cAMP-CREB pathway reverses working memory deficits during withdrawal from prolonged alcohol exposure. Brain Struct Funct. 2016 Mar;221(2):865-77.
CAS Number
– 93602-66-5
Molecular Weight
– 446.46
SMILES
– O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3.CCN(CC)CC
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE);PKA
Isoform
– PDE10;PDE3;PKA
Pathway
– Metabolic Enzyme/Protease;Stem Cell/Wnt
Product type
– Reference compound
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