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SOS1-IN-14
$610 – $3,050
Products Details
Product Description
– SOS1-IN-14 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817)[1].
Web ID
– HY-151517
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H29F3N6O2
References
– [1]He H, et al. Discovery of Orally Bioavailable SOS1 Inhibitors for Suppressing KRAS-Driven Carcinoma. J Med Chem. 2022 Sep 29.
CAS Number
– 2793405-20-4
Molecular Weight
– 550.57
Compound Purity
– 99.38
SMILES
– N#CC1(C(N2C[C@]3([H])CCOC4=CC5=NC(C)=NC(N[C@@H](C6=CC=CC(C(F)F)=C6F)C)=C5C=C4N3CC2)=O)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Ras
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
