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Sordarin (sodium)
$455 – $1,365
Products Details
Product Description
– Sordarin is a potent diphthamide-dependent eEF2 inhibitor with antifungal properties. Sordarin targets eEF2 so as to inhibit protein translation by blocking eEF2-mediated translocation of tRNAs. Sordarin inhibits translation specifically in certain fungi (e.g. C. albicans, C. glabrata, and C. neoformans) while unable to do so in some other fungal species (e.g. Candida parapsilosis and Candida lusitaniae)[1][2].
Web ID
– HY-126396
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H39NaO8
References
– [1]Wael Abdel-Fattah, et al. Insights into diphthamide, key diphtheria toxin effector. Toxins (Basel). 2013 May 3;5(5):958-68.|[2]Biprashekhar Chakraborty, et al. Structure-based designing of sordarin derivative as potential fungicide with pan-fungal activity. J Mol Graph Model. 2016 May;66:133-42.
CAS Number
– 463356-00-5
Molecular Weight
– 514.58
Compound Purity
– 99.0
SMILES
– O=C([C@]([C@]12C=O)(C(C(C)C)=C[C@H]3C1)[C@@]3(C[C@@]4([H])[C@@]2([H])CC[C@H]4C)CO[C@H](O[C@@H]5C)[C@H]([C@@H]([C@@H]5OC)O)O)O[Na]
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;CaMK;Fungal
Pathway
– Anti-infection;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
