Download Files:
Products Details
Product Description
– Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2].
Web ID
– HY-121577
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C19H28N2O3
References
– [1]Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165727.|[2]X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol’s metabolite KH176m. Sci Rep. 2021 Jan 13;11(1):880.|[3]Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel). 2020 Aug 7;13(8):184.
CAS Number
– 1541170-75-5
Molecular Weight
– 332.44
SMILES
– CC1=C(C(C)=C2CC[C@@](C(N[C@@H]3CCCNC3)=O)(OC2=C1C)C)O
Clinical Information
– Phase 2
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Reactive Oxygen Species
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
