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Products Details
Product Description
– Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].
Web ID
– HY-117229
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H11F3O3
References
– [1]Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74(1):63-75.
CAS Number
– 1221722-10-6
Molecular Weight
– 296.24
SMILES
– O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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