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Sodium Salicylate
$55 – $106
Products Details
Product Description
– Sodium Salicylate (Salicylic acid sodium salt) inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1]. Sodium Salicylate is also a S6K inhibitor.Sodium Salicylate is a NF-κB inhibitor that decreases inflammatory gene expression and improves repair in aged muscle[4].
Web ID
– HY-B0167A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C7H5NaO3
Citations
– Cancer Lett. 2021 Jan 1;496:127-133.|Biopharm Drug Dispos. 2022 Oct 4.|bioRxiv. 2023 Jun 3.|Food Chem. 2022: 134807.|Katedra farmakologie a toxikologie. 2020 Jul.|Plant Cell. 2022 Aug 16;koac255.
References
– [1]Dongmei Bai, et al. Palmitic acid negatively regulates tumor suppressor PTEN through T366 phosphorylation and protein degradation. Cancer Lett. 2020 Oct 8;S0304-3835(20)30506-1.|[2]Juhyun Oh, et al. Age-associated NF-κB signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 Nov; 8(11): 2871–2884.|[3]Mitchell JA, et al. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor kappaB) activation: role of arachidonic acid. Mol Pharmacol. 1997 Jun;51(6):907-12.|[4]Nixon M, et al. Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization. Diabetes. 2012 Apr;61(4):790-6.
CAS Number
– 54-21-7
Molecular Weight
– 160.10
Compound Purity
– 99.88
SMILES
– O=C(O[Na])C1=CC=CC=C1O
Clinical Information
– Launched
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Target
– Apoptosis;Autophagy;COX;Endogenous Metabolite;NF-κB;Ribosomal S6 Kinase (RSK)
Isoform
– COX-2;Microbial Metabolite
Pathway
– Apoptosis;Autophagy;Immunology/Inflammation;MAPK/ERK Pathway;Metabolic Enzyme/Protease;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
