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Products Details
Product Description
– SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity[1].
Web ID
– HY-150564
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H25F4N5O2
References
– [1]Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.
CAS Number
– 1822355-27-0
Molecular Weight
– 503.49
SMILES
– O=C(N(C)C1CCN(C(C2=CC=CC=C2NC3=CC=NN3C)=O)CC1)C4=CC=C(F)C=C4C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Hedgehog;Smo
Pathway
– Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
