Download Files:
Products Details
Product Description
– SMA4 is a selective PKG1α activator with basal EC50 value of 29 μM. SMA4 facilitates phosphorylation of the known PKG1 substrate, vasodilator-stimulated phosphoprotein (VASP), and inhibits human pulmonary arterial smooth muscle cells (hPASMC) proliferation. SMA4 can be used for cardiovascular disease research[1].
Web ID
– HY-155106
Shipping
– Room temperature
Molecular Formula
– C28H27Cl2N3O4
References
– [1]Metwally E, et al. Structural insights into selective small molecule activation of PKG1α. Commun Biol. 2023 Jul 31;6(1):798.
Molecular Weight
– 540.44
SMILES
– [H][C@]1(C2=CC=CC=C2)[C@](O[C@@H](CO)C3=CC(Cl)=CC(Cl)=C3)([H])CCCN1CC4=NC5=C(N4)C=CC(C(O)=O)=C5
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
