Download Files:
SM-164 Hydrochloride
$350 – $1,800
Products Details
Product Description
– SM-164 Hydrochloride is a cell-permeable Smac mimetic compound. SM-164 binds to XIAP protein containing both the BIR2 and BIR3 domains with an IC50 value of 1.39 nM and functions as an extremely potent antagonist of XIAP.
Web ID
– HY-15989A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C62H85ClN14O6
Citations
– J Ethnopharmacol. 2023 Nov 1:117373.|Biomed Res Int. 2019 Apr 7;2019:2121357.|Bioorg Chem. 2022: 106339.|Bioorg Chem. 2023 Jun 1;137:106647.|Bioorg Chem. 2024 Jan, 142, 106964.|Bioorg Med Chem. 2023 Aug 15, 91, 117385.|bioRxiv. 2023 Apr 25.|bioRxiv. 2023 Aug 24.|Cell Death Dis. 2018 Nov 15;9(12):1140. |Cell Res. 2023 Sep 19.|Curr Protoc. 2021 Jun;1(6):e156.|Eur J Med Chem. 2021 Apr 27;220:113484.|Eur J Med Chem. 2022 Jun 5;236:114345.|Int J Biol Macromol. 2023 Jun 13;125373.|J Cell Mol Med. 2023 Aug 29.|J Med Chem. 2022 Oct 26.|J Med Chem. 2023 Feb 23;66(4):3073-3087.|J Med Chem. 2023 Mar 12.|Mater Sci Eng C Mater Biol Appl. 29 December 2021, 112615.|Mol Neurobiol. 2023 Jan 5.|Patent. US20230192662A1.|Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2117396119.|Research Square Print. 2022 May.|Rheumatology. 2022 Oct 29;keac621.|Signal Transduct Target Ther. 2020 Oct 9;5(1):235.
References
– [1]Sun H, et al. Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP. J Am Chem Soc. 2007 Dec 12;129(49):15279-94.|[2]Lu J, et al. SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res. 2008 Nov 15;68(22):9384-93.
Molecular Weight
– 1157.88
Compound Purity
– 99.0
SMILES
– C[C@H](NC)C(N[C@H]1CCCC[C@](CC[C@H]2C(N[C@@H](C3=CC=CC=C3)C4=CN(CCCCC5=CC=C(CCCCN6N=NC([C@@H](NC([C@@H]7CC[C@@](CCCC[C@@H]8NC([C@@H](NC)C)=O)([H])N7C8=O)=O)C9=CC=CC=C9)=C6)C=C5)N=N4)=O)([H])N2C1=O)=O.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– H2O : ≥ 106 mg/mL
Target
– Apoptosis;IAP
Isoform
– cIAP;cIAP-1;cIAP-2
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
