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SM-1295
$820 – $6,800
Products Details
Product Description
– SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively[1][2].
Web ID
– HY-124181
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C29H36BrN5O4
References
– [1]Haiying Sun, et al. Potent and Selective Small-Molecule Inhibitors of cIAP1/2 Proteins Reveal That the Binding of Smac Mimetics to XIAP BIR3 Is Not Required for Their Effective Induction of Cell Death in Tumor Cells. ACS Chem Biol. 2014 Apr 18;9(4):994-1002.|[2]Hui Cong, et al. Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives. J Med Chem. 2019 Jun 27;62(12):5750-5772.
CAS Number
– 1562375-46-5
Molecular Weight
– 598.53
Compound Purity
– 98.71
SMILES
– O=C([C@@H]1CC[C@@](CCN(C(CC2=CC=CC=C2)=O)C[C@@H]3NC([C@@H](NC)C)=O)([H])N1C3=O)NCC4=CC=C(Br)C=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 310 mg/mL (ultrasonic)
Target
– Apoptosis;IAP
Pathway
– Apoptosis
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
