Download Files:
Products Details
Product Description
– SLP9101555 (compound 14c) is a potent and selective SphK2 (sphingosine kinase 2) inhibitor (Ki=90 nM) with 200-fold selectivity over SphK1. SLP9101555 markedly decreases extracellular S1P (sphingosine 1-phosphate) levels[1].
Web ID
– HY-150513
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H29ClF3N5O
References
– [1]Srinath Pashikanti, et al. Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. ACS Bio Med Chem Au 2022.
Molecular Weight
– 471.95
SMILES
– N=C(N1[C@H](C2=NC(C3=CC=C(CCC4CCCCC4)C(C(F)(F)F)=C3)=NO2)CCC1)N.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– SphK
Isoform
– SphK2
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
