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Products Details
Product Description
– SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with Kis of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research[1][2].
Web ID
– HY-120268A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H31ClF3N5O2
References
– [1]Yugesh Kharel, et al. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31.
CAS Number
– 1897379-34-8
Molecular Weight
– 489.96
SMILES
– N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– SphK
Isoform
– SphK2
Pathway
– Immunology/Inflammation
Product type
– Reference compound
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