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SLC26A3-IN-1
SKU
HY-149802-Get quote
Category Reference compound
Tags GLUT, Membrane Transporter/Ion Channel, Metabolic Disease
Products Details
Product Description
– SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
Web ID
– HY-149802
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C23H18O4
References
– [1]Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.
CAS Number
– 307552-53-0
Molecular Weight
– 358.39
SMILES
– O=C(C1=C(C2=CC=CC=C2)OC3=C1C=C(OCC4=C(C)C=CC=C4)C=C3)O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– GLUT
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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