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Products Details
Product Description
– SKLB0565 is a potent tubulin inhibitor. SKLB0565 shows significant anti-proliferative activity against CRC (colorectal carcinoma) cell lines, with IC50 values ranging from 0.012 μM to 0.081 μM. SKLB0565 causes G2/M phase arrest and mitochondria-mediated intrinsic apoptosis. SKLB0565 inhibits cell migration and disrupted the tube formation of HUVECs[1].
Web ID
– HY-147949
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H25ClN6O
References
– [1]Hu X, et al. Design, synthesis and biological evaluation of a novel tubulin inhibitor SKLB0565 targeting the colchicine binding site. Bioorg Chem. 2020 Apr;97:103695.
CAS Number
– 2414607-10-4
Molecular Weight
– 400.91
SMILES
– O=C1C(CNC2=C3N=CN(C4CCCC4)C3=NC(Cl)=N2)=C(CC)C=C(CC)N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Microtubule/Tubulin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Reference compound
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