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SKF 38393 (hydrochloride)
$86 – $462
Products Details
Product Description
– SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].
Web ID
– HY-12520A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H18ClNO2
Citations
– Behav Brain Res. 2022 Jan 17;113759.|bioRxiv. 2019 Oct.|bioRxiv. 2020 Jun.|EMBO Rep. 2022 Jan 17;e53191.|Med Sci Monit. 2021 Oct 18;27:e933278.|Microbiome. 2020 Aug 20;8(1):120.|Neurobiol Aging. 2021 Jun;102:1-16.|Free Radic Biol Med. 2023 Mar 23;202:2-16.
References
– [1]Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84(1):257-64.|[2]Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892(2):241-7.|[3]Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70.|[4]Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222.
CAS Number
– 62717-42-4
Molecular Weight
– 291.77
Compound Purity
– 99.44
SMILES
– OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 34 mg/mL|H2O : 10 mg/mL (ultrasonic)
Target
– Dopamine Receptor
Isoform
– D1 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
