SK-575-NEG

$898

Only 1000 item(s) left in stock.

Products Details

Product Description

– SK-575-NEG (compound 28), a methylation counterpart of SK-575, is synthesized by methylation of the amino group of piperidine-2,6-dione in SK-575 as an control compound. SK-575-NEG is strongly bound to PARP1, with an IC50 of 2.64 nM. SK-575-NEG was completely ineffective in inducing PARP1 degradation in MDA-MB-436 and Capan-1 cells at concentrations up to 1 μM[1].

Web ID

– HY-147101

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C48H55FN8O8

References

– [1]Cao C, et al. Discovery of SK-575 as a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. J Med Chem. 2020 Oct 8;63(19):11012-11033.

CAS Number

– 2523017-04-9

Molecular Weight

– 891.00

SMILES

– O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCCCCCCCCCC(NCCNC4=CC=CC(C(N5C6C(N(C)C(CC6)=O)=O)=O)=C4C5=O)=O)=O)=O)=C2)F)C7=C1C=CC=C7

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– PARP

Isoform

– PARP1

Pathway

– Cell Cycle/DNA Damage;Epigenetics

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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