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Products Details
Product Description
– SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM. SIRT5 inhibitor 5 does not occupy the NNAD+ -binding pocket and acts as a substrate-competitive inhibitor[1].
Web ID
– HY-152214
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C21H14ClN3O3S
References
– [1]Yao J, et al. Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors. Eur J Med Chem. 2022 Dec 16;247:115024.
CAS Number
– 2883730-60-5
Molecular Weight
– 423.87
SMILES
– CC1=NN(C(/C1=C/C2=CC=C(C=C2)C(O)=O)=O)C3=NC(C4=CC=C(C=C4)Cl)=CS3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Sirtuin
Isoform
– SIRT5
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
