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Products Details
Product Description
– Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer[1].
Web ID
– HY-145958
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H26N6O3S
References
– [1]Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823.
CAS Number
– 2243151-81-5
Molecular Weight
– 502.59
SMILES
– O=C(C1=CN(C)N=C1)NC2=CC=C(C=C2)OCC3=CC(NC(CSC4=NC(C)=CC(C)=N4)=O)=CC=C3
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Sirtuin
Isoform
– SIRT2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
