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Products Details
Product Description
– Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].
Web ID
– HY-155727
Shipping
– Room temperature
Molecular Formula
– C18H14N4O3S2
References
– [1]Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.
CAS Number
– 670267-73-9
Molecular Weight
– 398.46
SMILES
– O=S(NC1=CC(SC2=NN=CN2)=C(C3=C1C=CC=C3)O)(C4=CC=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Sirtuin
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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