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Sirt1/2-IN-1
SKU
HY-146013-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics, Microtubule/Tubulin;Sirtuin
Products Details
Product Description
– Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].
Web ID
– HY-146013
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H13ClN2OS2
References
– [1]Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926.
CAS Number
– 2402779-21-7
Molecular Weight
– 420.93
SMILES
– O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin;Sirtuin
Isoform
– SIRT1;SIRT2;SIRT3
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.