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Products Details
Product Description
– Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].
Web ID
– HY-146013
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H13ClN2OS2
References
– [1]Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926.
CAS Number
– 2402779-21-7
Molecular Weight
– 420.93
SMILES
– O=C1CSC2=NC(C3=CC(Cl)=CC=C3S4)=C4C(C5=CC=C6C=CC=CC6=C5)N21
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin;Sirtuin
Isoform
– SIRT1;SIRT2;SIRT3
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
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