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Products Details
Product Description
– SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer[1].
Web ID
– HY-150568
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C46H63N9O8S2
References
– [1]Li R , et al. A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine[J]. Bioorganic & Medicinal Chemistry, 2020, 28(7):115356.
CAS Number
– 2413212-06-1
Molecular Weight
– 934.18
SMILES
– O=C([C@@H](NC1=O)CCSC)NCCCCCOC2=CC=C(C=C2)C[C@@H]1NC([C@H](CCCCNC(C)=S)NC([C@@H]3CC4=CC=C(OCCCC(N[C@H](C(N3)=O)CC5=CN=CN5)=O)C=C4)=O)=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Sirtuin
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
