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Products Details
Product Description
– SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research[1]
Web ID
– HY-149846
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C32H27NO2S
References
– [1]Hengphasatporn K,et.al. Sulfonylated Indeno[1,2-c]quinoline Derivatives as Potent EGFR Tyrosine Kinase Inhibitors. ACS Omega. 2023 May 23;8(22):19645-19655.
CAS Number
– 2151881-74-0
Molecular Weight
– 489.63
SMILES
– O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– EGFR
Pathway
– JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
