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Products Details
Product Description
– Simvastatin-d3 is the deuterium labeled Simvastatin[1]. Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[2].
Web ID
– HY-17502S1
Shipping
– Room temperature
Molecular Formula
– C25H35D3O5
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Slater, E.E., et al. Mechanism of action and biological profile of HMG CoA reductase inhibitors. A new therapeutic alternative. Drugs, 1988. 36 Suppl 3: p. 72-82.
CAS Number
– 1002347-61-6
Molecular Weight
– 421.58
SMILES
– CCC(C([2H])([2H])[2H])(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Ferroptosis;HMG-CoA Reductase (HMGCR);Mitophagy
Pathway
– Apoptosis;Autophagy;Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
