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Products Details
Product Description
– Simvastatin Acyl-β-D-glucuronide is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM[1][2].
Web ID
– HY-136344
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C31H48O12
References
– [1]Prueksaritanont T, Subramanian R, Fang X, et al. Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization. Drug Metab Dispos. 2002;30(5):505‐512.
CAS Number
– 463962-56-3
Molecular Weight
– 612.71
SMILES
– O=C(C(C)(C)CC)O[C@@H](C1)[C@@]([C@H]2CC[C@@H](O)C[C@@H](O)CC(O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)C(O)=O)=O)([H])C(C=C[C@@H]2C)=C[C@@H]1C
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
