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Products Details
Product Description
– Siegesbeckialide I most potently inhibits LPS-induced NO production in RAW264.7 murine macrophages by directly binding to IKKα/β.
Web ID
– HY-N10111
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H28O6
References
– [1]Gao X, et al. Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β. J Nat Prod. 2021 Nov 26;84(11):2808-2821.
Molecular Weight
– 364.43
SMILES
– C/C=C(C)C(OC[C@@H]1CC/C=C(CO)C[C@@H](O)[C@@H]2[C@H](OC(C2=C)=O)C1)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– IKK
Pathway
– NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
