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Products Details
Product Description
– SHP844 is a SHP2 inhibitor with the IC50 of 18.9 µM. SHP2 is a protein tyrosine phosphatase (PTP) that regulates tyrosine phosphorylation levels and is involved in cell proliferation, differentiation and survival[1].
Web ID
– HY-125260
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H24ClN5O6
References
– [1]Michelle Fodor, et al. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 Mar 16;13(3):647-656.
CAS Number
– 2222280-82-0
Molecular Weight
– 573.98
SMILES
– O=C(O)[C@H]1N(C(C2=CC=C(CN3C4=NN=C(C5=CC=CC(OC)=C5O)N4C6=C(C=CC=C6)C3=O)C(Cl)=C2)=O)CCC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– SHP2
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
