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SHIP2-IN-1
$166 – $2,250
Products Details
Product Description
– SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1].
Web ID
– HY-112700
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C17H13Cl2FN4O
References
– [1]Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer’s disease. Eur J Med Chem. 2018 Sep 5;157:405-422.
CAS Number
– 2252247-80-4
Molecular Weight
– 379.22
Compound Purity
– 99.72
SMILES
– FC1=C(Cl)C([C@@H](C)OC2=CN=CC(C3=CN=C(N)N=C3)=C2)=C(Cl)C=C1
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Phosphatase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
