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Products Details
Product Description
– SGLT inhibitor-1 is a potent dual inhibitor of sodium glucose co-transporter proteins (SGLTs), inhibits hSGLT1 and hSGLT2 with IC50s of 43 nM and 9 nM, respectively[1].
Web ID
– HY-112807
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C24H27FO8
References
– [1]Xu G， et al. Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors. Bioorg Med Chem Lett. 2018 Nov 15;28(21):3446-3453.
CAS Number
– 2247314-23-2
Molecular Weight
– 462.46
SMILES
– OC[C@@H]1[C@@H](F)[C@H](O)[C@@H](O)[C@H](C2=CC(CC3=CC(OCCO4)=C4C=C3)=C(OCC5)C5=C2OC)O1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– SGLT
Isoform
– SGLT1;SGLT2
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
