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Products Details
Product Description
– SGL5213 is a potent, oral active and low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor, with IC50 values of 29 nM and 20 nM for hSGLT1 and hSGLT2, respectively. SGL5213 has potential to treat type 2 diabetes treatment[1].
Web ID
– HY-114308
Shipping
– Room temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C37H55N3O8
References
– [1]Kuroda S, et al. Discovery of potent, low-absorbable sodium-dependent glucose cotransporter 1 (SGLT1) inhibitor SGL5213 for type 2 diabetes treatment. Bioorg Med Chem. 2019 Jan 15;27(2):394-409.
CAS Number
– 1240305-17-2
Molecular Weight
– 669.85
SMILES
– COC1=C([C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)C=C(CC3=CC=C(/C=C/C(C)(C)C(NC(C)(C)C(NCCN(C)C)=O)=O)C=C3)C(C(C)C)=C1
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– SGLT
Isoform
– SGLT1
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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