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Products Details
Product Description
– sEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC50=0.5 μM). sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases[1].
Web ID
– HY-151616
Shipping
– Room temperature
Molecular Formula
– C22H22F3N3O2S
References
– [1]Turanlı S, et al. Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition. ACS Omega. 2022 Oct 5;7(41):36354-36365.
Molecular Weight
– 449.49
SMILES
– O=C(C1=CC(N=C(SCC2=CC=CC=C2C(F)(F)F)N3)=C(C=C1)C3=O)NCC(C)(C)C
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Epoxide Hydrolase
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
