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Products Details
Product Description
– sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of sEH (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC50 values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively[1].
Web ID
– HY-145833A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C35H39ClF3N5O3
References
– [1]Codony S, et al. Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease. J Med Chem. 2022 Mar 24;65(6):4909-4925.
CAS Number
– 2490589-12-1
Molecular Weight
– 670.16
SMILES
– O=C(N1CCC(CC1)NC(NC2=CC=C(C=C2)OC(F)(F)F)=O)CCCCNC3=C4C(C[C@H]5C[C@@H]4CC(C)=C5)=NC6=CC(Cl)=CC=C63
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);Epoxide Hydrolase
Isoform
– AChE;BChE
Pathway
– Metabolic Enzyme/Protease;Neuronal Signaling
Product type
– Reference compound
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