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Seco-Duocarmycin TM
SKU
HY-130083-Get quote
Category ADC Related
Tags ADC Cytotoxin;DNA Alkylator/Crosslinker, Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage, Cancer
Products Details
Product Description
– Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC)[1].
Web ID
– HY-130083
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H24N2O6
References
– [1]Gieseg MA, et al. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA. Anticancer Drug Des. 1999 Feb;14(1):77-84.
CAS Number
– 236102-87-7
Molecular Weight
– 448.47
SMILES
– OC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;DNA Alkylator/Crosslinker
Isoform
– Duocarmycins
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Product type
– ADC Related
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