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SDZ 224-015
SKU
HY-141622-10 mg
Category Reference compound
Tags Anti-infection;Apoptosis;Immunology/Inflammation, Caspase;Interleukin Related;SARS-CoV, Infection; Inflammation/Immunology
$400 – $3,500
Products Details
Product Description
– SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and caspase-1. SDZ 224-015 possesses anti-COVID-19 activity, targeting Mpro (IC50 of 30 nM)[1][2].
Web ID
– HY-141622
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C30H35Cl2N3O9
References
– [1]P R Elford, et al. Reduction of inflammation and pyrexia in the rat by oral administration of SDZ 224-015, an inhibitor of the interleukin-1 beta converting enzyme. Br J Pharmacol. 1995 Jun;115(4):601-6.|[2]Martin A Redhead, et al. Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19. Sci Rep. 2021 Jun 24;11(1):13208.
CAS Number
– 161511-45-1
Molecular Weight
– 652.52
Compound Purity
– 95.49
SMILES
– O=C(OCC1=CC=CC=C1)N[C@@H](C(C)C)C(N[C@@H](C)C(N[C@@H](CC(OCC)=O)C(COC(C2=C(C=CC=C2Cl)Cl)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Infection; Inflammation/Immunology
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Caspase;Interleukin Related;SARS-CoV
Isoform
– IL-1
Pathway
– Anti-infection;Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.