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Products Details
Product Description
– SDOX is the Doxorubicin (DOX) proagent. The loaded DOX proagents (SDOX) which can release the parent agents DOX triggered by excessive GSH in tumor cells, minimize the unexpected side effects on normal tissues without compromising the potency[1].
Web ID
– HY-144769
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C69H97NO20S2
References
– [1]Yi Zhao, et a l. pH-redox responsive cascade-targeted liposomes to intelligently deliver doxorubicin prodrugs and lonidamine for glioma. Eur J Med Chem. 2022 May 5;235:114281.
CAS Number
– 2921601-78-5
Molecular Weight
– 1324.63
SMILES
– C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OCCOCCOCCOC(CCC(OCCSSCCOC(N[C@H]4C[C@@H](O[C@H]([C@H]4O)C)O[C@@H]5C6=C(C[C@](O)(C5)C(CO)=O)C(O)=C7C(C(C8=C(OC)C=CC=C8C7=O)=O)=C6O)=O)=O)=O)([H])[C@@]9([H])[C@](CC3)([C@@](CC9)([H])[C@H](C)CCCC(C)C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Topoisomerase
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
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